Key Differences Between Hemophilia C and Hemophilia A and B

Table 1. Key Differences Between Hemophilia C and Hemophilia A and B
Key Characteristic	Difference Between Hemophilia C and Hemophilia A & B
Incidence	Hemophilia C is more common among persons of Ashkenazi (European) Jewish descent.1,2 Hemophilia A and B affect all racial and ethnic groups equally.
Bleeding tendency	The frequency of bleeding with hemophilia C is not determined by the patient’s factor level or severity of the deficiency. Hemophilia C affects men and women equally. In hemophilia C, unpredictable (or inconsistent) bleeding patterns can complicate management. Individuals with hemophilia C are not likely to bleed spontaneously (or without known injury); bleeding tends to occur after trauma or surgery. Unlike hemophilia A and B, hemophilia C is not commonly associated with bleeding into joints and muscles. Physical signs of the disorder (e.g., bruising) are rare.
Cause	Hemophilia C is primarily an inherited autosomal disorder Unlike hemophilia A and hemophilia B, it is not linked to the X chromosome and affects both genders equally
Treatment	Individuals with hemophilia C do not require treatment or prophylactic (preventive) therapy for daily activities. Replacement therapy is required for dental extractions and surgery Treatment options depend on the type of procedure. Individuals with hemophilia C may experience milder symptoms than those living with hemophilia A or B, but they still require effective treatment to achieve optimal outcomes after surgeries or injuries

Source :
http://www.ihtc.org/medical-professionals/blood-disorders/bleeding-disorders/hemophilia-c/